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Osteogenesis Imperfecta


Osteogenesis imperfecta is a genetic disorder causing fragile bones.


  • Gene mutation
  • Autosomal dominant inheritance


  • Fractures
  • Loose joints
  • Curved spine
  • Brittle teeth
  • Weak muscles
  • Hearing loss
  • Easy bruising and bleeding
  • Respiratory problems
  • Short stature

There is no cure for osteogenesis imperfecta but bone strength can be increased by:

  • Bisphosphonates and other medication
  • Physiotherapy
  • Support devices like casts, braces, walkers, etc.
  • Surgery to implant rods and correct deformities

There is no known way to prevent osteogenesis imperfecta.